Endocrine Abstracts

Introduction: The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors affect innate immunity. A fully working peripheral CRF system is present in adipose tissue. In obesity, macrophages and adipocytes interact causing local and systemic inflammation. In addition, macrophages and adipocytes share common characteristics including production of inflammatory cytokines in response to lipopolysaccharides (LPS) via the toll-like receptor-4 (TLR4) which b...